The index closed 9.42 points lower after dropping 1.38 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange decreased by 11% to VND13.933 trillion (US$548.3 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 25 tickers fell.
MWG of electronics retail chain Mobile World saw the biggest drop of 2.84%, followed by POW of electricity producer Petrovietnam Power Corporation with a 2.77% decline and VRE of retail real estate arm Vincom Retail, down 2.3%.
Five blue chips gained. SAB of brewer Sabeco went up 2.1%, PLX of fuel distributor Petrolimex rose 0.7%, and VCB of state-owned lender Vietcombank closed 0.5% higher.
Foreign investors were net seller to the tune of VND651 billion, mainly selling FPT of IT giant FPT Corporation and MWG.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.30%, while the UPCoM-Index for the Unlisted Public Companies Market was steady.
Global shares were mixed on Wednesday as markets digested political turmoil in South Korea, where martial law was imposed and then lifted hours later, and France, where an upcoming no-confidence vote also put the euro in the spotlight, Reuters reported.
South Korea’s benchmark KOSPI index down 1.4%, taking its year-to-date losses to over 7% and making it the worst performing major stock market in Asia this year.
In turn, MSCI’s broadest index of Asia-Pacific shares outside Japan, which counts Samsung Electronics as one of its top constituents, was mostly flat.
Most Asian markets aside from South Korea rose.
Meanwhile, in Europe, stocks edged up 0.2% and the euro traded near a two-year low ahead of the no-confidence vote in France, where the blue-chip CAC 40 was up 0.4%.